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天然化合物

カタログ番号	製品名	別名	ターゲット
T7356	PTP1B-IN-1	PTP1B inhibitor	Phosphatase
	PTP1B-IN-1 (PTP1B inhibitor) is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B) (IC50 : 1.6 mM)		Phosphatase
T4256	PTP1B-IN-2		Phosphatase
	PTP1B-IN-2 is an effective protein tyrosine phosphatase 1B (PTP1B) inhibitor(IC50=50 nM).		Phosphatase
T12579	RAMB4	PTP1B-IN-9	Proteasome
	RAMB4 (PTP1B-IN-9) is a ubiquitin-proteasome system (UPS)-stressor,with anticancer activity.		Proteasome
T4340	SPI-112		Phosphatase
	SPI-112, the SPI-112 methyl ester analog, can inhibit cellular Shp2 PTP activity. SPI-112 bound to Shp2 by surface plasmon resonance (SPR) and displayed competitive inhibitor kinetics to Shp2.		Phosphatase
T24073	PTP1B-IN-4	NUN 17724,PTP1B-inhibitor-2,PTP1B IN 2,PTP1B-IN-2,PTP1B-inhibitor-4,FRJ,PTP1B inhibitor 4,NUN17724,PTP1B inhibitor 2,PTP1BIN2,NUN-17724	Phosphatase
	PTP1B-IN-4 (NUN-17724) is an allosteric PTP1B inhibitor with an IC50 of 8 μM. PTP1B-IN-4 can be used in studies about obesity and diabetes.		Phosphatase
T9921	Infliximab		TNF
	Infliximab is a humanized antibody against tumor necrosis factor α TNF-α) that is used in the treatment of Crohn's disease and rheumatoid arthritis.		TNF
T23133	Pentamidine		Phosphatase , Antibacterial , Antibiotic , Parasite , Antifungal
	Pentamidine is an antifungal and antiprotozoal agent, interacting directly with the pathogen genome by binding to AT-rich regions of duplex DNA and the minor groove of DNA, thereby interfering with DNA replication.
T7704	KY-226		Phosphatase
	KY-226 is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B)(IC50: 0.25 μM,)		Phosphatase
T28410	PHPS1	PHPS-1,PHPS 1	Phosphatase
	PHPS1 is an inhibitor of Shp2. PHPS1 efficiently inhibits activation of Erk1/2 by the leukemia-associated Shp2 mutant, Shp2-E76K, and blocks the anchorage-independent growth of a variety of human tumor cell lines.		Phosphatase
T1654	Pentamidine isethionate	Pentamidine isethionate salt,Pentamidine diisethionate	Phosphatase , Antibacterial , Antibiotic , Parasite , Antifungal
	Pentamidine isethionate (Pentamidine diisethionate) is a synthetic amidine derivative, Pentamidine Isethionate is an antiprotozoal and antifungal agent.
T23132	Pentamidine dihydrochloride	MP-601205 dihydrochloride	Phosphatase , Antibacterial , Antibiotic , Parasite , Antifungal
	Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an aromatic diamidine agent with activity against a number of microorganisms including protozoa (Trypanosoma brucei, Leishmania spp., and Babesia spp.) and fungi...
T22276	Bis(maltolato)oxovanadium(IV)	BMOV,Bis maltolato oxovanadium,Bis(maltolato)oxovanadium (IV),bis maltolato oxo vanadium,Bis(maltolato)oxovanadium (IV)	Phosphatase , Others
	Bis(maltolato)oxovanadium(IV) (BMOV) is a potent, reversible, competitive and orally active pan-PTP (protein tyrosine phosphatases)inhibitor with insulin-mimicking effects and anti-diabetic properties. BMOV is a potent i...		Phosphatase , Others
T12578	(E,E)-RAMB4	PTP1B-IN-8	Phosphatase
	PTP1B-IN-8 is a potent and selective inhibitor of protein tyrosine phosphatase-1B (PTP1B).		Phosphatase
T9938	RA371	EX-A4742	Others
	RA371 (EX-A4742) is a derivative of PTP1B-IN-8, an inhibitor of PTP1B.		Others
T12577	PTP1B-IN-3		Phosphatase
	PTP1B-IN-3 is a selective and potent PTP1B inhibitor with anticancer activity that inhibits PTP1B and TCPTP.PTP1B-IN-3 is used in the study of diabetes.		Phosphatase
T67893	PTP1B-IN-22		Phosphatase
	PTP1B-IN-22 is a protein tyrosine phosphatase 1B (PTP1B) inhibitor that inhibits glucose uptake in skeletal muscle L6 myotubes.		Phosphatase
T7381	TCS 401		Phosphatase
	TCS 401 is a selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B; Ki = 0.29 µM)		Phosphatase
T7084	2-Bromo-4'-hydroxyacetophenone	SHP-1 Inhibitor II,PTP Inhibitor I,α-Bromo-4-hydroxyacetophenone,4-Hydroxyphenacyl bromide	Phosphatase
	2-Bromo-4'-hydroxyacetophenone(PTP Inhibitor I) is a cell-permeable, protein tyrosine phosphatase (PTP) inhibitor that covalently blocks the catalytic domain of the Src homology region 2 domain-containing phosphatase (SH...		Phosphatase
T22137	PTP Inhibitor IV		Others
	PTP Inhibitor IV is an effective protein tyrosine phosphatase (PTP) inhibitor, which can selectively inhibit DUSP14 phosphatase activity (IC50.5.21μm). PTP Inhibitor IV inhibited SHP-2, PTP1B, PTp-ε, PTP Meg-2, PTP-σ, PT...		Others
T13013	Sodium stibogluconate	Stibogluconate trisodium nonahydrate	Phosphatase
	Sodium stibogluconate (Stibogluconate trisodium nonahydrate) is a potent protein tyrosine phosphatase inhibitor.		Phosphatase
T16724	Razuprotafib	AKB-9778	Phosphatase , Others
	Razuprotafib (AKB-9778) is a protein tyrosine phosphatase ß (HPTPß) inhibitor (IC50: 50 nM). Razuprotafib is effective for the activation of Tie-2 and is protective against acute kidney injury.		Phosphatase , Others
T40745	PTP1B-IN-13	PTP1B-IN-13
	PTP1B-IN-13, a potent and selective inhibitor of Protein Tyrosine Phosphatase 1B (PTP1B), effectively targets the allosteric site, exhibiting an IC50 value of 1.59 μM.
T63435	PTP1B-IN-16
	PTP1B-IN-16 is a promising and selective benzimidazole derivative and an inhibitor of protein tyrosine phosphatase 1B (PTP1B) (Ki: 12.6 μM).PTP1B-IN-16 can be used to study type 2 diabetes.
T61851	PTP1B-IN-3 diammonium
	PTP1B-IN-3 diammonium is a highly effective and orally bioavailable inhibitor of the protein tyrosine phosphatase 1B (PTP1B) enzyme, with an IC50 value of 120 nM for both PTP1B and TCPTP. This compound exhibits potent an...
T63022	PTP1B-IN-18
	PTP1B-IN-18 is an orally active, fully mixed protein tyrosine phosphatase 1B (PTP1B) inhibitor (Ki: 35.2 μM).PTP1B-IN-18 can be used to study type 2 diabetes.
T63739	PTP1B-IN-15
	PTP1B-IN-15 is a potent and selective protein tyrosine phosphatase 1B (PTP1B) inhibitor that has shown research potential in type II diabetes and obesity.
T40835	PTP1B-IN-14	PTP1B-IN-14
	PTP1B-IN-14 is a selective inhibitor of Protein Tyrosine Phosphatase 1B (PTP1B) that targets the allosteric site, exhibiting an inhibitory concentration (IC50) value of 0.72 μM.
T63021	PTP1B-IN-17
	PTP1B-IN-17 (Compound 45) is a selective benzimidazole derivative with potential as a protein tyrosine phosphatase 1B (PTP1B) inhibitor (Ki: 30.2 μM).PTP1B-IN-17 can be used in the study of type 2 diabetes.
T15166	DPM-1001		Phosphatase
	DPM-1001 is an orally bioavailable and non-competitive protein-tyrosine phosphatase (PTP1B) inhibitor (IC50: 100 nM) with the anti-diabetic property.		Phosphatase
T15243	Ertiprotafib	PTP 112	Phosphatase , PPAR
	Ertiprotafib is a PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist inhibitor ( IC50s: 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM for PPARα/PPARβ).		Phosphatase , PPAR
T63023	PTP1B-IN-19
	PTP1B-IN-19 (Compound 43) is a promising selective benzimidazole derivative as a protein tyrosine phosphatase 1B (PTP1B) inhibitor (Ki: 23.3 μM).PTP1B-IN-17 can be used to study type 2 diabetes.
T69633	TCS-401
	TCS-401 is an insulin receptor sensitizing agent; Selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B).
T25953	PHPS1 Sodium	PHPS1 Na,PHPS1 Sodium salt
	PHPS1 sodium is a potent and selective inhibitor of Shp2, with Kis of 0.73, 5.8, 10.7, 5.8, and 0.47 μM for Shp2, Shp2-R362K, Shp1, PTP1B, and PTP1B-Q, respectively [1].
T78702	PTP1B/AKR1B1-IN-1		Phosphatase
	PTP1B/AKR1B1-IN-1 is a dual inhibitor targeting protein tyrosine phosphatase 1B (PTP1B) and aldose reductase (AKR1B1), exhibiting inhibitory potency with IC50s of 0.06 μM for PTP1B and 4.3 μM for AKR1B1. Additionally, it...		Phosphatase
T11730	JTT 551		Others
			Others
T72216	DPM-1001 trihydrochloride
	DPM-1001 trihydrochloride, an analog of the specific protein-tyrosine phosphatase (PTP1B) inhibitor MSI-1436, is a potent, specific, non-competitive, orally active inhibitor of PTP1B with an IC50 of 100 nM, exhibiting an...
T78703	PTP1B/AKR1B1-IN-2		Phosphatase
	PTP1B/AKR1B1-IN-2 (Compound 7f) is a potent inhibitor targeting both PTP1B and AKR1B1 with IC50 values of 3.2 and 2.1 μM, respectively, and K i values of 4.0 and 0.9 μM. This compound acts as an insulin mimetic and enhan...		Phosphatase
T41018	CPT-157633
	CPT-157633 is a difluoro-phosphonomethyl phenylalanine derivative that acts as a potent inhibitor of the enzyme PTP1B. It effectively prevents the development of glucose intolerance induced by binge drinking.
T79845	Anticancer agent 144		Phosphatase
	Compound 144 (also known as Anticancer Agent 144) is a potent inhibitor of both PTPN2 and PTP1B, exhibiting IC50 values of less than 2.5 nM, making it suitable for cancer research applications [1].		Phosphatase
T79844	Anticancer agent 143		Phosphatase
	Anticancer Agent 143 (Compound 369), a potent dual inhibitor targeting PTPN2 and PTP1B, exhibits IC50 values below 2.5 nM. It is employed in cancer research [1].		Phosphatase
T35877	MurA-IN-1
	MurA-IN-1 (compound 1a), a PTPRR inhibitor, exhibits IC50 values of 0.09 μM for PTPRR, 0.23 μM for PTP1B, 0.75 μM for PTPN7, and 0.8 μM for PTPN5, respectively, targeting a family of human MAPK-specific protein tyrosine ...
T39167	GS-493
	GS-493, a highly specific protein tyrosine phosphatase SHP2 (PTPN11) inhibitor, exhibits remarkable potency with an IC50 of 71 nM. It displays 29- and 45-fold greater affinity towards SHP2 compared to its related counter...
T79479	MptpB-IN-2		Antibiotic
	MptpB-IN-2 (compound 20), a selective inhibitor for mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB), exhibits half maximal inhibitory concentrations (IC50) of 0.64 μM for MptpB, 4.06 μM for MptpA, and 4...		Antibiotic

Compounds

PTP1B-IN-1

T7356

Synonym: PTP1B inhibitor

Synonym: PTP1B-IN-9

Synonym: NUN 17724,PTP1B-inhibitor-2,PTP1B IN 2,PTP1B-IN-2,PTP1B-inhibitor-4,FRJ,PTP1B inhibitor 4,NUN17724,PTP1B inhibitor 2,PTP1BIN2,NUN-17724

Target: Phosphatase, Antibacterial, Antibiotic, Parasite, Antifungal

Synonym: PHPS-1,PHPS 1

Target: Phosphatase

Pentamidine isethionate

T1654

Synonym: Pentamidine isethionate salt,Pentamidine diisethionate

Target: Phosphatase, Antibacterial, Antibiotic, Parasite, Antifungal

Pentamidine dihydrochloride

T23132

Synonym: MP-601205 dihydrochloride

Target: Phosphatase, Antibacterial, Antibiotic, Parasite, Antifungal

Bis(maltolato)oxovanadium(IV)

T22276

Synonym: BMOV,Bis maltolato oxovanadium,Bis(maltolato)oxovanadium (IV),bis maltolato oxo vanadium,Bis(maltolato)oxovanadium (IV)

Target: Phosphatase, Others

(E,E)-RAMB4

T12578

Synonym: PTP1B-IN-8

2-Bromo-4'-hydroxyacetophenone

T7084

Synonym: SHP-1 Inhibitor II,PTP Inhibitor I,α-Bromo-4-hydroxyacetophenone,4-Hydroxyphenacyl bromide

Sodium stibogluconate

T13013

Synonym: Stibogluconate trisodium nonahydrate

Target: Phosphatase, Others

PTP1B-IN-13

T40745

Synonym: PTP1B-IN-13

PTP1B-IN-3 diammonium

Synonym: PTP1B-IN-14

Target: Phosphatase, PPAR

Synonym: PHPS1 Na,PHPS1 Sodium salt

DPM-1001 trihydrochloride

カタログ番号	製品名	別名	ターゲット
TN1990	Norathyriol		Akt , DNA/RNA Synthesis , AMPK , PPAR
	Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.		Akt , DNA/RNA Synthesis , AMPK , PPAR
TN1956	Mulberrofuran G		Phosphatase , HBV , Glucosidase
	Mulberrofuran G, isolated from Morus alba L., has anti-hepatitis B virus activity and protects against ischemic injury-induced cell death. Mulberrofuran G is a dual inhibitor of PTP1B and alpha-glucosidase for use in the...		Phosphatase , HBV , Glucosidase
TN1470	Cassiaside B2		Phosphatase , MAO , 5-HT Receptor
	Cassiaside B2 is an inhibitor of protein tyrosine phosphatase 1B (PTP1B) and human monoamine oxidase A (hMAO-A).Cassiaside B2 is an agonist of the 5-HT2C receptor with anti-allergic activity.Cassiaside B2 is one of the a...		Phosphatase , MAO , 5-HT Receptor
TN1691	Glabrol		P450 , NF-κB , NO Synthase , Acyltransferase
	Glabrol is a PTP1B inhibitor, it is also a CYP1B1 inhibitor, it shows inhibition of CYP1B1 in live cell assay with the IC50 value of 15uM.		P450 , NF-κB , NO Synthase , Acyltransferase
T3851	Vicenin 2	Vicenin -2	RAAS
	Vicenin 2 is an angiotensin-converting enzyme (ACE) inhibitor (IC50=43.83 μM) from the aerial parts of Desmodium styracifolium. Vicenin 2 is an inhibitor of α-glucosidase, PTP1B, and RLAR. Vicenin 2 has hepatoprotective,...		RAAS
T3S1612	Kuwanon G	Moracenin B,Kuwanone G	Phosphatase , Antibacterial , Bombesin Receptor , AChR , AChE , Glucosidase
	1. Kuwanon G (Moracenin B) as dual inhibitors of PTP1B and α-glucosidase enzymes, as well as insulin sensitizers, it may potentially be utilized as an effective treatment for Type II diabetes mellitus. 2. Kuwanon G has a...
T73073	PTP1B-IN-21
	PTP1B-IN-21 is a compound that functions as a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B; IC50=1.56 μM), demonstrating a marked preference over the structurally similar T-cell protein tyrosine phosphat...
TN3335	Abyssinone V		Phosphatase
	Abyssinone V is a natural compound isolated from the stem bark of Erythrina melanacantha and an inhibitor of protein tyrosine phosphatase-1B (PTP1B).		Phosphatase
TN2913	3-Acetoxy-11-ursen-28,13-olide		Phosphatase
	3β-Acetoxy-urs-11-en-28,13-olide exhibits significant protein tyrosine phosphatase 1B (PTP1B) inhibitory activity, it is a mixed-type PTP1B inhibitor. It exhibits weak-moderate antiproliferative activity against the A278...		Phosphatase
T73072	PTP1B-IN-20
	PTP1B-IN-20 is a selective PTP1B (protein tyrosine phosphatase 1B) inhibitor, exhibiting an IC50 of 1.05 μM, and demonstrates selectivity over TCPTP (T-cell protein tyrosine phosphatase), which has an IC50 of 78.0 μM. Th...
T75495	Rubrofusarin 6-O-β-D-glucopyranoside
	Rubrofusarin 6-O-β-D-glucopyranoside, a glycosidic derivative of Rubrofusarin, functions as an inhibitor of protein tyrosine phosphatase 1B (PTP1B) with an IC50 value of 87.36 μM. It is utilized in research investigating...
TN4279	Isoderrone		Tyrosinase
	Isoderrone shows inhibitory effects on α-glucosidase in vitro; it is a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with IC50 value of 22.7 ± 1.7 uM, suggests that it may be a new drug for treatment of type 2 diabe...		Tyrosinase
T79985	Cryptosporioptide A		Phosphatase
	Cryptosporioptide A (Compound 3), a protein tyrosine phosphatase inhibitor, originates from the insect-parasitic fungus Cordyceps gracilioides. This compound effectively inhibits several enzymes including PTP1B, SHP2, CD...		Phosphatase
T38069	Aquastatin A
	Aquastatin A is a fungal metabolite originally isolated fromF. aquaeductuumthat has diverse biological activities.1It is active againstS. aureus(MIC = 32 μg/ml) and inhibits enoyl-acyl carrier protein reductase (Fabl; IC...